Hypothyroidism and dna Research Paper Example | Topics and Well Written Essays - 500 words

Hypothyroidism and dna - Research Paper Example According to Lavin (2009), hypothyroidism can be termed as thyroid hormone deficiency whereby the thyroid hormone levels in the body have no effects on the body tissues as required. He notes that thyroid hormones deficiency has numerous negative impacts on the overall functioning of the body tissues (Lavin, 2009). How does hypothyroidism affect DNA? It affects DNA by interfering with the usage of the messages carried by the DNA and DNA transcription. By binding to the receptors found on the nucleus of each cell, DNA transcription is affected. Hence, hypothyroidism leads to low levels of transcription of DNA. It reduces DNA synthesis (Thurlbeck & Churg, 1995). The cause of hypothyroidism could be injury to the thyroid gland. An illness such as Hashimoto’s thyroiditis can cause it. It leads to the production of antibodies that destroy the thyroid gland. Such illness is regarded to as an autoimmune disease. If the pituitary gland is destroyed or is not functioning properly, then thyroid hormone production is reduced. Some medications like lithium cause hypothyroidism. (Harvard Health Publications; White, & Garber, 2010). Genetics is can be used to explain how DNA mutation and alteration cause hypothyroidism. When there are DNA changes in various genes, then this can cause congenital hypothyroidism. The number of chromosomes also leads to hypothyroidism (Valente, Hosford-Dunn, & Roeser, 2008). DNA and hypothyroidisim have an intricate relationship. Ptaff (2002) asserts that relations of thyroid hormone with the proteins that bind Deoxyribonucleic acid is the main means through which thyroid hormone controls transcription of thyroid hormone-responsive genes (Ptaff, 2002). In hypothyroidism, DNA methyltransferase activity is regulated more while that of histone acetylases is regulated less (Acton, 2012). The thyroid –stimulating hormone ÃŽ ² gene defect has been found in various families with hypothyroidism. The defect in the

Week 6 students discussions answers Assignment Example | Topics and Well Written Essays - 500 words

Week 6 students discussions answers - Assignment Example However, administrators may allow wish to deny employs access to some sites, as such, they can add them to the restricted sites zone. At home, some websites can be added to restricted sites zone, to prevent kids from accessing them. Additionally, I concur with Joshua that often updating of IE is important wince it helps prevent security vulnerabilities. However, Joshua fails to explain what need to be considered before the decision to update is considered. Before deciding what needs to be updated that a CIO considers whether certain important add-ons, extensions, and plugins would be compatible with the new version. I agree with Catherine that the SmartScreen filter is an important component of the IE responsible of monitoring traffic for any evidence of phishing activity, and as such, should not be disabled, especially in a business setting. I tend to disagree with Catherine’s notion that as long as an older version of IE is working correctly, there is no need for updating to a newer one. Updating to a newer version prevents any sort of security vulnerabilities that might arise. I agree with Joshua that restricting the applications run on a workstation helps prevent security vulnerabilities; and it is the responsibility of the system and network administrators to test applications for vulnerabilities and ensure that vulnerable applications are not run on computers. I also agree with Joshua, that as an end user, I would be agitated with the policy of restricting application being run on a computer due to security reasons, since such restricted applications, may be important to me. I do not agree with Joshua that developer’s hard coding is responsible for the occurrence of application compatibility bugs. In my opinion, application compatibility bugs may occur as a result of updating to a newer operating system. I an organizational context, once the operating system has been updated, it is important that compatible applications

Financial System and Intermediaries Assignment Example | Topics and Well Written Essays - 1000 words

Financial System and Intermediaries - Assignment Example This role is performed by intermediaries by taking the advantage of economies of scale while markets do the same by facilitating offer and trade of assets that comprise investors’ portfolios (Gup, 2011, Pg. 11) Financial intermediaries are the financial institutions such as banks, building societies, investment banks pension funds or insurance companies. Financial intermediaries include insurance companies that offer risk investment, financial advisers who offer specialist advice saving the investor costs and time in looking for the most suitable investment. Credit unions provide facilities for depositing and lending within a certain community and investment trusts or mutual funds that pool small savings of individual investors to enable a bigger investment trust. They enable small investors to enjoy smaller commission rates that are available on big purchases (Allen and Gale, 2001, Pg. 501). Commercial banks are intermediaries that issue among others savings account deposits. With a 100 000, the investor can open a savings account that will earn interest annually. They carry interest payments and offer time deposits. In this case, interests are earned with fixed terms to maturity (Gup, 2011, Pg. 47). Mutual funds raise funds through the sales of shares to individuals as well as institutions. The shares are pooled to buy a diversified portfolio of bonds, stocks or both. A mutual fund intermediary may keep some of the cash for other investment opportunities that may come up in the future (Gup, 2011, Pg. 82). An investor may also require an adviser as a financial intermediary to help in making the right choice of institution to invest with. Advisers spare investors time and resources that may be spent in the process of looking for a suitable investment bank, firm or institution (Gup, 2011, Pg 87). There are numerous banks in the UK that offer financial services to people all over the world. Barclays bank is

(Dual Relationship) discuss the statment that in examing dual Essay

(Dual Relationship) discuss the statment that in examing dual relationships the most important issue is exploitation not duality - Essay Example Dual relationship in psychotherapy can be focused on the fact that the therapist has other existing or subsequent relationship to the patient. This relationship can either be in terms of the social aspect, financial aspect or even profession aspect. When the term dual is attributed it does not limit the issue on the concurrent relationships. Based on the opinions of the professionals the, it is important to prevent dual relationships due to the effects that can be brought about in the treatment of the patients. Basically, the relationship between therapists and patients should remain purely professional due to the probability that the medical treatments and interventions can be affected by the dual relationships that occur between the therapists and the patients. The optimum level of health care that can be given cannot be achieved if the main concern of the therapist can be affected by other issues due to the other relationship with the patient. In this case, the professionalism and the ethical issues are often considered and needed as guidelines. There are other issues that are needed to be co... But is important to consider that the cases wherein blood ties are considered as the connection between the therapist and the patient, it is still considered as a situation that is below the optimum expected. Another issue is related to the ethical considerations that can be attached to such relationships (Pope and Vetter, 1992). A. Types of Dual Relationships The main types of dual relationships are considered to be able to determine the proper actions that can be undertaken. These types are considered as the major ones which include the double roles, the double professions, the double financial relationships and the unavoidable dual relationships. The double roles can be defined as the type wherein the client or the therapist is connected in other ways. An example is the therapist may be a former student of the client. The said relationship can still be considered to have certain effects on the performance of the procedure. The relationship can be considered as relevant since it is one of the most common categories (Borys and Pope, 1989). Double professions on the other hand deals with the people that are into different professions and lines of work simultaneously. This is one of the reasons that these professionals meet people that may get their professional service. For example the therapist can at the same time be into the academe, thus students can also be clients (Borys and Pope, 1989). There are also cases of dual relationships that can be considered as inevitable and at some point a necessity. This can occur in cases such as the military wherein the officers may at the same time be therapists and medical professionals, thus are licensed to

JACOBSTOWE Essay Example | Topics and Well Written Essays - 1500 words

JACOBSTOWE - Essay Example Jacobstowe found it difficult in 2007 to meet its working capital requirements. With low gearing, tight liquidity problems, working capital could not be utilized to its best. But despite all these adversaries, Jacob declared good dividend in order to maintain the market price of its scrips at certain predetermined level. All ventures in the business are executed to earn the profits, and that is one of the most important tasks of business managers. Three ratios are used, namely Net Profit Margin, Return on Assets, and Return on Equity in order to evaluate the profitability of Jacobstowe Plc. a) Net Profit Margins: Jacobstowe Plc.’s net profit margins have gone down to 5.17% in 2007 from 6.42% in 2006. Despite the fact that there is increase in turnover from 5,622m to 5,996m, Jacobstowe has not been able to increase net profit margins. There could be a number of reasons for such a fall in profitability. One would notice that current ratio of Jacobstowe has also fallen in the year 2007 as compared to 2006 even when total ‘Receivables’ have increased; it makes sense here to state that turnover would have increased at the cost of reduction in prices, and thus there are reduction in net margins. Initially with the reduction in prices gross margin would have gone down but as there was also increase in operating costs (those increased from 5099m in 2006 to 5486m in 2007), both factors would have worked together to bring down the net margins. b) Return on Assets (ROA): Another measure to assess profitability is Return on Assets (ROA). Return on assets in 2007 is 4.93 as compared 5.75 in 2006. Assets have performed if not less than their optimum capacity but certainly the performance was what it was in the year 2006. For calculation purposes average capital employed in 2006 is taken as in 2007. This is because of non- availability of information about ‘total assets employed’ in 2005. Profitability on this count was also not very encouraging. The

Reflective Report On Class Debate Essay Example | Topics and Well Written Essays - 1000 words

Reflective Report On Class Debate - Essay Example The report concludes with the learning outcome on how arguments over a topic are developed, structured and evaluated in a debate. Discussion The motion of the report was that the companies should have limits or makes a fixed value for the wage of the senior management in the companies. My team members were against the motion of the debate i.e. the companies should not put limits or doesn’t make a fixed value for the remuneration of senior management in their compensation policy. First, my team members worked hard in identifying the possible arguments that supports our point of view and go against the topic of the debate. Secondly, my team members organise and structure the arguable points in the most meaningful manner that convinces the opponent debating group. My group members would have worked better if we had used some known evidence or statistics from literature and research. My Team Members’ Argument The key points developed in support of the argument were to discu ss the idea and purpose of the compensation system and policy, addressing the worth of senior management for companies in a broader context, the changing perspectives on the reasons why management wages are not kept fixed, and identifying reasons that justify the extended worth of senior management. Before arguing over the topic, it is important to first understand the rationale behind the wage system and policy of companies. The compensation policy by which companies reward their employees is not a mere system of paying off workers for their time and efforts, rather a compensation policy is often a strategic competitive edge by which companies retain the human capital to their organisations for a longer period of... This paper approves that the key points presented by the opponents were that wage discrimination leads to professional jealousy, influences motivation, detainment of financial resources around senior management and that performance criterion are reflective of job description, responsibility and skills. The other side argued that the companies should have limits for wages of senior management, as this wage discrimination creates a negative internal competition, decreases employee motivation and professional jealously amongst the lower and top management employees. Management personnel and seniors in a company serve as assets because; one, there is no substitute of experience; second, the cost of attracting new talent is too stupendous than retaining the old ones. This paper makes a conclusion that when preset performance standards systematically justify the professional worth of every individual irrespective of the management level then what is the reason for delimiting the wage scale for senior management on behalf of their extended worth? It is an unfair company policy which consumes a large proportion of organisational financial resources for around a small group of individuals. This limits a company’s ability to leverage and transfer benefits to a major portion of employees working for that company. The strength of the argument was it develops logical link between the supporting statements, though the researchers and authors have commented on both the arguments and there is no right conclusion for this debate found in the research.

Consequences Of Noncompliance With The AEDA Lessons To Be Learned Essay

Consequences Of Noncompliance With The AEDA Lessons To Be Learned - Essay Example That is why Congress first passed in 1967 what has come to be known as The Age Discrimination in Employment Act of 1967, with subsequent amendments and ruling which would follow as the years passed. According to the online page for The U.S. Equal Employment Opportunity Commission, it has this to say about the congressional act, "The Age Discrimination in Employment Act of 1967 (ADEA) protects individuals who are 40 years of age or older from employment discrimination based on age. The ADEA's protections apply to both employees and job applicants. Under the ADEA, it is unlawful to discriminate against a person because of his/her age with respect to any term, condition, or privilege of employment, including hiring, firing, promotion, layoff, compensation, benefits, job assignments, and training," (Equal Employment #1). In understanding this law, it is crucial to understand the facts behind it. According to this group, this act covers employers who have 20 or more employees, and also happens to cover both state and local governments. The group goes on to say that the protections for such persons under the act are as such: "It is generally unlawful for apprenticeship programs, including joint labor-management apprenticeship programs, to discriminate on the basis of an individual's age. Age limitations in apprenticeship programs are valid only if they fall within certain specific exceptions under the ADEA or if the EEOC grants a specific exemption." Job Notices and Advertisements "The ADEA generally makes it unlawful to include age preferences, limitations, or specifications in job notices or advertisements. A job notice or advertisement may specify an age limit only in the rare circumstances where age is shown to be a "bona fide occupational qualification" (BFOQ) reasonably necessary to the normal operation of the business." Pre-Employment Inquiries "The ADEA does not specifically prohibit an employer from asking an applicant's age or date of birth. However, because such inquiries may deter older workers from applying for employment or may otherwise indicate possible intent to discriminate based on age, requests for age information will be closely scrutinized to make sure